|
Symbol Name ID |
Lgi1
leucine-rich repeat LGI family, member 1 MGI:1861691 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Focal sensory seizure with olfactory features |
Bilateral tonic-clonic seizure |
Bilateral tonic-clonic seizure with focal onset |
Focal impaired awareness seizure |
Focal aware seizure |
Focal aware sensory seizure with auditory features |
Focal automatism seizure |
Focal clonic seizure |
Focal sensory seizure with auditory features |
Focal sensory seizure with cephalic sensation |
Focal sensory seizure with vestibular features |
Focal sensory seizure with visual features |
Deja vu aura |
Focal autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena |
Focal autonomic seizure with palpitations/tachycardia/bradycardia/asystole |
| Disease(s) Associated with LGI1 | |||||||||||||||
| familial temporal lobe epilepsy 1 |
| Mouse Phenotypes | nervous system phenotype |
increased susceptibility to pharmacologically induced seizures |
seizures |
environmentally induced seizures |
audiogenic seizures |
clonic seizures |
tonic seizures |
tonic-clonic seizures |
abnormal spike wave discharge |
abnormal axon pruning |
abnormal cerebellum external granule cell layer morphology |
abnormal hippocampal mossy fiber morphology |
abnormal cerebral cortex morphology |
abnormal neocortex morphology |
abnormal cerebellar granule cell morphology |
gliosis |
abnormal dendrite morphology |
abnormal synapse morphology |
neurodegeneration |
abnormal brain wave pattern |
abnormal synaptic transmission |
abnormal CNS synaptic transmission |
decreased excitatory postsynaptic current amplitude |
increased excitatory postsynaptic current amplitude |
abnormal glutamate-mediated receptor currents |
abnormal miniature excitatory postsynaptic currents |
decreased miniature excitatory postsynaptic current amplitude |
abnormal paired-pulse facilitation |
abnormal paired-pulse inhibition |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||
| Lgi1tm1.1Ics/Lgi1tm1.1Ics | ||||||||||||||||||||||||||||||
| Lgi1tm1Mafu/Lgi1tm1Mafu | * | |||||||||||||||||||||||||||||
| Lgi1tm1.1Ics/Lgi1+ | ||||||||||||||||||||||||||||||
| Lgi1tm1Mafu/Lgi1+ | ||||||||||||||||||||||||||||||
| Tg(Lgi1)#Mpan/0 | ||||||||||||||||||||||||||||||
| Tg(Lgi1*)#Mpan/0 | ||||||||||||||||||||||||||||||
| Lgi1tm2.1Jkc/Lgi1tm2.1Jkc Tg(CMV-cre)1Cgn/0 (conditional) |
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| Lgi1tm2.1Jkc/Lgi1tm2.1Jkc Tg(Nes-cre)1Kln/0 (conditional) |
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| Lgi1tm2.1Jkc/Lgi1tm2.1Jkc Pvalbtm1(cre)Arbr/0 (conditional) |
* | |||||||||||||||||||||||||||||
| Lgi1tm2.1Jkc/Lgi1tm2.1Jkc Tg(Camk2a-cre)T29-1Stl/0 (conditional) |
* | |||||||||||||||||||||||||||||
| Lgi1tm2.1Jkc/Lgi1tm2.1Jkc Tg(GFAP-cre)25Mes/0 (conditional) |
* | |||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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